BMS-5

BMS-5 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 with IC50 values of 7 and 8 nM, respectively. LIMK1 and LIMK2 participate in signal pathways affecting actin dynamics by deactivating cofilin. This compound can be used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin.Formal Name: N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-2-methyl-propanamide. CAS Number: 1338247-35-0. Synonyms: LIM Kinase Inhibitor I, LIMKi 3. Molecular Formula: C17H14Cl2F2N4OS. Formula Weight: 431.3. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 25 mg/ml, DMSO:PBS (pH 7.2)(1:5): 0.2 mg/ml, Ethanol: 1 mg/ml. lambdamax: 297 nm. SMILES: ClC1=C(N2N=C(C(F)F)C=C2C3=CN=C(NC(C(C)C)=O)S3)C(Cl)=CC=C1. InChi Code: InChI=1S/C17H14Cl2F2N4OS/c1-8(2)16(26)23-17-22-7-13(27-17)12-6-11(15(20)21)24-25(12)14-9(18)4-3-5-10(14)19/h3-8,15H,1-2H3,(H,22,23,26). InChi Key: IVUGBSGLHRJSSP-UHFFFAOYSA-N.