Zu "K05744" wurden 42 Artikel gefunden!
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NEU
Anti-Recombinant LIMK-2, clone C111794
Artikelnummer: E-AN302174L.100
Protein function: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and...
| Schlagworte: | Anti-LIMK2, Anti-LIM domain kinase 2, Recombinant LIMK-2 Monoclonal Antibody |
| Anwendung: | WB, IHC, IF, IP, ELISA |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human,mouse,rat |
ab 171,00 €
Recombinant Human LIMK2 Protein
Artikelnummer: ABS-PP-26274-L.100
Tag: C-His. Modification: unmodified. Start Site: Ser141. End Site: Ser320. Coverage: 0.29. Isoelectric Point: 9. Core Sequence: SVQEQLPYSV TLISMPATTE GRRGFSVSVE SACSNYATTV QVKEVNRMHI SPNNRNAIHP GDRILEINGT PVRTLRVEEV EDAISQTSQT LQLLIEHDPV SQRLDQLRLE ARLAPHMQNA GHPHALSTLD TKENLEGTLR RRSLRRSNSI SKSPGPSSPK EPLLFSRDIS...
| Schlagworte: | LIMK2, LIM domain kinase 2 |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 22.5 kD |
ab 115,00 €
Recombinant Human LIMK2 Protein
Artikelnummer: ABS-PP-26274.100
Tag: C-His. Modification: unmodified. Start Site: Ser141. End Site: Ser320. Coverage: 0.29. Isoelectric Point: 9. Core Sequence: SVQEQLPYSV TLISMPATTE GRRGFSVSVE SACSNYATTV QVKEVNRMHI SPNNRNAIHP GDRILEINGT PVRTLRVEEV EDAISQTSQT LQLLIEHDPV SQRLDQLRLE ARLAPHMQNA GHPHALSTLD TKENLEGTLR RRSLRRSNSI SKSPGPSSPK EPLLFSRDIS...
| Schlagworte: | LIMK2, LIM domain kinase 2 |
| Exprimiert in: | E.coli |
| Ursprungsart: | human |
| MW: | 22.5 kD |
ab 90,00 €
BMS-5
Artikelnummer: SYN-1024-M001
Soluble in DMSO. Kinases, such as LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2), have been identified as participating in signal pathways affecting actin dynamics by deactivating cofilin. Over expression of LMK1 has been found in invasive breast and prostate cancer cell lines and suppression of LIMK 2 expression has...
| Schlagworte: | BMS5 |
| Anwendung: | LIMK1 / LIMK2 inhibitor |
| CAS | 1338247-35-0 |
| MW: | 431,3 D |
ab 123,00 €
BMS-5
Artikelnummer: Cay21072-1
BMS-5 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 with IC50 values of 7 and 8 nM, respectively. LIMK1 and LIMK2 participate in signal pathways affecting actin dynamics by deactivating cofilin. This compound can be used to study the role of activated LIMK isoforms in the signaling of Rho...
| Schlagworte: | LIM Kinase Inhibitor I, LIMKi 3,... |
| Anwendung: | LIMK1 / LIMK2 inhibitor |
| CAS | 1338247-35-0 |
| MW: | 431.3 D |
ab 74,00 €
BMS-3
Artikelnummer: AG-CR1-2901-M005
Off-white solid. Soluble in DMSO (5mg/ml). Potent LIMK (Lim kinase) inhibitor. Has IC50 values of 5nM and 6nM for LIMK1 and LIMK2, respectively.
| Schlagworte: | N-(5-(1-(2,6-Dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl)thiazol-2- yl)cyclopropanecarboxamide |
| Anwendung: | Potent LIMK inhibitor |
| CAS | 1338247-30-5 |
| MW: | 429,3 D |
ab 88,00 €
TH263
Artikelnummer: Cay37295-5
TH263 is an inactive analog of the inhibitor of LIM kinase 1 (LIMK1) and LIMK2 TH257 (Cay-34236) that has been used as a negative control for the kinase activity of LIMK1 and LIMK2.Formal Name: N-(phenylmethyl)-4-[[(phenylmethyl)amino]sulfonyl]-benzamide. CAS Number: 313520-94-4. Molecular Formula: C21H20N2O3S....
| Schlagworte: | N-(phenylmethyl)-4-[[(phenylmethyl)amino]sulfonyl]-benzamide |
| Anwendung: | TH257 inactive kinase inhibitor analog, control |
| CAS | 313520-94-4 |
| MW: | 380.5 D |
ab 134,00 €
TH-257
Artikelnummer: TGM-T7128-5mg
Description: TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM). Target: LIM Kinase. Smiles: CCCCN(Cc1ccccc1)C(=O)c1ccc(cc1)S(=O)(=O)Nc1ccccc1. References: Fabrizio M . Recent advances in the rational design and development of LIM kinase inhibitors are not enough...
| Schlagworte: | TH 257 |
| Anwendung: | LIMK1 / LIMK2 inhibitor |
| CAS | 2244678-29-1 |
| MW: | 422.54 D |
ab 34,00 €
Anti-LIMK2
Artikelnummer: ARG55700.100
Protein function: Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. [The UniProt Consortium]
| Schlagworte: | Anti-LIMK2, Anti-LIMK-2, EC=2.7.11.1, Anti-LIM domain kinase 2 |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
616,00 €
Anti-LIM Kinase 2 / LIMK2
Artikelnummer: NSJ-R32136
0.5mg/ml if reconstituted with 0.2ml sterile DI water. LIM domain kinase 2 is an enzyme that in humans is encoded by the LIMK2 gene. There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc...
| Schlagworte: | Anti-LIMK2, Anti-LIMK-2, EC=2.7.11.1, Anti-LIM domain kinase 2, LIM Kinase 2 Antibody / LIMK2 |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
790,00 €
BMS-3
Artikelnummer: Cay19421-1
BMS-3 is a potent inhibitor of activated LIM domain kinases LIMK1 and LIMK2 (IC50s = 5 and 6 nM, respectively). It is used to study the role of activated LIMK isoforms in the signaling of Rho family GTPases to cytoskeletal proteins, including cofilin and tubulin.Formal Name:...
| Schlagworte: | N-[5-[1-(2,6-dichlorophenyl)-3-(difluoromethyl)-1H-pyrazol-5-yl]-2-thiazolyl]-cyclopropanecarboxamide |
| Anwendung: | LIMK1 / LIMK2 inhibitor |
| CAS | 1338247-30-5 |
| MW: | 429.3 D |
ab 51,00 €
LX7101 (hydrochloride)
Artikelnummer: Cay21209-1
LX7101 is a potent inhibitor of LIM kinase (LIMK) 1 and 2 and Rho-associated kinase 1 (ROCK1) and ROCK2 with IC50 values of 32, 4.3, 69, and 32 nM, respectively. It is selective, showing no cross reactivity in a panel of binding assays including 78 receptors and transporters and 430 additional kinases, at a...
| Schlagworte: | N,N-dimethyl-carbamic acid,... |
| Anwendung: | LIMK2 inhibitor |
| CAS | 2319882-48-7 |
| MW: | 488 D |
ab 104,00 €