AZ 3146

AZ 3146 is an inhibitor of the monopolar spindle 1 (Mps1) checkpoint kinase (IC50 = 35 nM). It displays selectivity over 46 other kinases including Cdk1 and Aurora kinase B. It has been shown to inhibit the recruitment of Mad1, Mad2, and centromere protein E (CENP-E) to kinetochores. AZ 3146 can be used with GSK923295 (Cay-18389), an inhibitor of CENP-E, to generate aneuploidy in cells.Formal Name: 9-cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one. CAS Number: 1124329-14-1. Synonyms: Mps1 Inhibitor III. Molecular Formula: C24H32N6O3. Formula Weight: 452.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 0.3 mg/ml, Ethanol: 2 mg/ml. lambdamax: 276, 302 nm. SMILES: CN1CCC(OC2=CC(OC)=C(NC3=NC=C(N(C)C(N4C5CCCC5)=O)C4=N3)C=C2)CC1. InChi Code: InChI=1S/C24H32N6O3/c1-28-12-10-17(11-13-28)33-18-8-9-19(21(14-18)32-3)26-23-25-15-20-22(27-23)30(24(31)29(20)2)16-6-4-5-7-16/h8-9,14-17H,4-7,10-13H2,1-3H3,(H,25,26,27). InChi Key: YUKWVHPTFRQHMF-UHFFFAOYSA-N.