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HUMAN TTK Peptide Pool
Artikelnummer: PE-LB01756.1
Pool of 212 overlapping peptides derived from a peptide scan (15mers with 11 aa overlap) through Dual specificity protein kinase TTK (UniProtKB - P33981) of homo sapiens. One unit allows the stimulation of 2,5 x 10^8 cells.You can find applications and references in our blog post: Esophagogastric adenocarcinoma:...
| Schlagworte: | PYT, TTK, MPS1, Dual specificity protein kinase TTK, Phosphotyrosine picked threonine-protein kinase |
| Ursprungsart: | human |
391,00 €
Mps1-IN-1
Artikelnummer: TGM-T12102-100mg
Description: Mps1-IN-1 is a potent, selective, and ATP-competitive inhibitor of Mps1 kinase (IC50: 367 nM). Target: Others. Smiles: COc1cc(ccc1Nc1cc(Nc2ccccc2S(=O)(=O)C(C)C)c2cc[nH]c2n1)N1CCC(O)CC1. References: Kwiatkowski N, et al. Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. Nat...
| Anwendung: | Selective MPS1 inhibitor |
| CAS | 1125593-20-5 |
| MW: | 535.66 D |
ab 40,00 €
NMS-P715
Artikelnummer: TGM-T12237-100mg
Description: NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM). Target: MAPK, MELK, Kinesin, Casein Kinase. Smiles: CCc1cccc(CC)c1NC(=O)c1nn(C)c-2c1CCc1cnc(Nc3ccc(cc3OC(F)(F)F)C(=O)NC3CCN(C)CC3)nc-21. References: Colombo R, et al. Targeting the mitotic checkpoint for cancer therapy...
| Anwendung: | Mps1 (TTK) inhibitor |
| CAS | 1202055-32-0 |
| MW: | 676.73 D |
ab 72,00 €
Mps1-IN-3
Artikelnummer: TGM-T16130-100mg
Description: Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM). Target: Kinesin. Smiles: COc1cc(ccc1Nc1nc(Nc2ccccc2S(=O)(=O)C(C)C)c2nc[nH]c2n1)N1CCC(O)CC1. References: Tannous BA, et al. Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J...
| Anwendung: | Serine/threonine-protein kinase TTK/MPS1 inhibitor |
| CAS | 1609584-72-6 |
| MW: | 537.63 D |
ab 42,00 €
BAY1217389
Artikelnummer: TGM-T3434-10mg
Description: BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM). Target: Kinesin. Smiles: COc1ccc(Oc2cc(NCCC(F)(F)F)c3ncc(-c4ccc(C(=O)NC5CC5)c(C)c4)n3n2)c(F)c1F. References: Wengner AM, et al. Mol Cancer Ther. 2016, 15(4):583-92.
| Anwendung: | TTK inhibitor |
| CAS | 1554458-53-5 |
| MW: | 561.5 D |
ab 34,00 €
MPS1/TTK Inhibitor
Artikelnummer: TGM-T37050-100mg
Description: MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK, IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. It inhibits MPS1 phosphorylation of kinetochore scaffold 1 (KNL1) and increases the rate of mitosis and the...
| Schlagworte: | MPS1/TTK Inhibitor |
| Anwendung: | MPS1/TTK inhibitor |
| CAS | 1202055-39-7 |
| MW: | 580.72 D |
ab 1.520,00 €
Mps1-IN-2
Artikelnummer: TGM-T1839-1mg
Description: Mps1-IN-2 is a potent, selective, and ATP-competitive inhibitor of both Mps1 and Plk1. Target: Kinesin, PLK. Smiles: CCOc1cc(ccc1Nc1ncc2N(C)C(=O)CCN(C3CCCC3)c2n1)N1CCC(O)CC1. References: Kwiatkowski N, et al. Nat Chem Biol. 2010 May,6(5):359-68.
| Anwendung: | MPS1 inhibitor |
| CAS | 1228817-38-6 |
| MW: | 480.6 D |
34,00 €
Anti-TTK (Ab-676)
Artikelnummer: CSB-PA586001.100
Host Species: Rabbit. Isotype: IgG. Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Storage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Purification Method: The antibody was affinity-purified from rabbit antiserum by...
| Schlagworte: | Anti-TTK, Anti-PYT, Anti-MPS1, Anti-Dual specificity protein kinase TTK, Anti-Phosphotyrosine picked threonine-protein... |
| Anwendung: | ELISA, WB, IHC |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
283,00 €
Mps1-IN-3
Artikelnummer: Cay41029-10
Mps1-IN-3 is an inhibitor of monopolar spindle 1 (Mps1, IC50 = 50 nM). It inhibits the proliferation of U251 glioblastoma cells (IC50 = ~5 µM). Mps1-IN-3 (2 µM) prevents checkpoint-mediated mitotic arrest induced by nocodazole (Cay-13857) in U2OS osteosarcoma cells and, when used at a concentration of 5 µM in...
| Schlagworte: | Monopolar Spindle 1 Inhibitor 3, Monopolar Spindle1-IN-3, Mps1 Inhibitor 3,... |
| Anwendung: | Serine/threonine-protein kinase TTK/MPS1 inhibitor |
| CAS | 1609584-72-6 |
| MW: | 537.6 D |
ab 81,00 €
BAY 12-17389
Artikelnummer: Cay21660-1
BAY 12-17389 is an inhibitor of monopolar spindle 1 (Mps1, IC50 = 0.63 nM). It is selective for Mps1 over a panel of kinases at 10 nM. BAY 12-17389 promotes cell-cycle progression into mitosis in metaphase-arrested HeLa cells (IC50 = 11 nM). BAY 12-17389 (1.5 mg/kg) enhances paclitaxel-induced inhibition of tumor...
| Schlagworte: | N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl-... |
| Anwendung: | TTK inhibitor |
| CAS | 1554458-53-5 |
| MW: | 561.5 D |
ab 52,00 €
Mps1-IN-1
Artikelnummer: Cay19175-1
Mps1-IN-1 is a selective inhibitor of monopolar spindle 1 (Mps1) kinase (IC50 = 367 nM), a dual-specificity kinase involved in spindle assembly checkpoint and the maintenance of chromosomal stability. It exhibits greater than 1,000-fold selectivity against a panel of 352 kinases. Mps1-IN-1 has been shown to disrupt...
| Schlagworte: | Monopolar Spindle 1 Kinase Inhibitor 1, Mps1 Kinase Inhibitor 1,... |
| Anwendung: | Selective MPS1 inhibitor |
| CAS | 1125593-20-5 |
| MW: | 535.7 D |
ab 47,00 €
Mps1-IN-2
Artikelnummer: Cay19401-1
Mps1-IN-2 is an ATP-competitive inhibitor of the checkpoint kinase Mps1 (IC50 = 145 nM). It is 1,000-fold selective for Mps1 over a panel of 352 kinases at 10 µM, but does inhibit Plk1 (Kd = 61 nM).Formal Name:...
| Schlagworte: | 9-cyclopentyl-2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,7,8,9-tetrahydro-5-methyl-6H-pyrimido[4,5-b][1,4]dia... |
| Anwendung: | MPS1 inhibitor |
| CAS | 1228817-38-6 |
| MW: | 480.6 D |
ab 44,00 €