Zu "K08866" wurden 28 Artikel gefunden!
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BAY 12-17389
Artikelnummer: Cay21660-1
BAY 12-17389 is an inhibitor of monopolar spindle 1 (Mps1, IC50 = 0.63 nM). It is selective for Mps1 over a panel of kinases at 10 nM. BAY 12-17389 promotes cell-cycle progression into mitosis in metaphase-arrested HeLa cells (IC50 = 11 nM). BAY 12-17389 (1.5 mg/kg) enhances paclitaxel-induced inhibition of tumor...
| Schlagworte: | N-cyclopropyl-4-[6-(2,3-difluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-b]pyridazin-3-yl]-2-methyl-... |
| Anwendung: | TTK inhibitor |
| CAS | 1554458-53-5 |
| MW: | 561.5 D |
ab 50,00 €
Mps1-IN-1
Artikelnummer: Cay19175-1
Mps1-IN-1 is a selective inhibitor of monopolar spindle 1 (Mps1) kinase (IC50 = 367 nM), a dual-specificity kinase involved in spindle assembly checkpoint and the maintenance of chromosomal stability. It exhibits greater than 1,000-fold selectivity against a panel of 352 kinases. Mps1-IN-1 has been shown to disrupt...
| Schlagworte: | Monopolar Spindle 1 Kinase Inhibitor 1, Mps1 Kinase Inhibitor 1,... |
| Anwendung: | Selective MPS1 inhibitor |
| CAS | 1125593-20-5 |
| MW: | 535.7 D |
ab 46,00 €
Mps1-IN-2
Artikelnummer: Cay19401-1
Mps1-IN-2 is an ATP-competitive inhibitor of the checkpoint kinase Mps1 (IC50 = 145 nM). It is 1,000-fold selective for Mps1 over a panel of 352 kinases at 10 µM, but does inhibit Plk1 (Kd = 61 nM).Formal Name:...
| Schlagworte: | 9-cyclopentyl-2-[[2-ethoxy-4-(4-hydroxy-1-piperidinyl)phenyl]amino]-5,7,8,9-tetrahydro-5-methyl-6H-pyrimido[4,5-b][1,4]dia... |
| Anwendung: | MPS1 inhibitor |
| CAS | 1228817-38-6 |
| MW: | 480.6 D |
ab 43,00 €
Mps1/TTK Inhibitor
Artikelnummer: Cay25554-1
Mps1/TTK inhibitor is an inhibitor of monopolar spindle 1 (Mps1/TTK, IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. It inhibits Mps1 phosphorylation of kinetochore scaffold 1 (KNL1) and increases the rate of mitosis and the number of cells...
| Schlagworte: | N-(2,6-diethylphenyl)-4,5-dihydro-8-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-1-methyl-1H-pyrazolo[4,3-h]quinazo... |
| Anwendung: | Dual specificity protein kinase TTK inhibitor |
| CAS | 1202055-39-7 |
| MW: | 580.7 D |
ab 65,00 €
NMS-P715
Artikelnummer: Cay31613-1
NMS-P715 is an inhibitor of the spindle assembly checkpoint kinase Mps1/TTK (IC50 = 0.182 µM). It is selective for Mps1/TTK over a panel of 59 additional kinases (IC50s = >5 µM for all). NMS-P715 (1 µM) accelerates mitosis, reducing the length of mitosis by approximately 3-fold, in U2OS cells. It induces aneuploidy...
| Schlagworte: | N-(2,6-diethylphenyl)-4,5-dihydro-1-methyl-8-[[4-[[(1-methyl-4-piperidinyl)amino]carbonyl]-2-(trifluoromethoxy)phenyl]amin... |
| Anwendung: | Mps1 (TTK) inhibitor |
| CAS | 1202055-32-0 |
| MW: | 676.7 D |
ab 73,00 €
Anti-TTK
Artikelnummer: A300-296A
Protein function: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. [The UniProt Consortium]
| Schlagworte: | Anti-TTK, Anti-PYT, Anti-MPS1, EC=2.7.12.1, Anti-Dual specificity protein kinase TTK, Anti-Phosphotyrosine picked... |
| Anwendung: | IP |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human |
ab 164,00 €
TTK, GST-tag
Artikelnummer: BPS-40291
Recombinant human TTK, full length, with N-terminal GST-tag, expressed by Sf9 insect cells via a baculovirus expression system.
| Schlagworte: | PYT, TTK, MPS1, Dual specificity protein kinase TTK, Phosphotyrosine picked threonine-protein kinase, |
| Anwendung: | Enzyme kinetics, inhibitor screening, selectivity profiling |
| Exprimiert in: | insect cells |
| Ursprungsart: | human |
| MW: | 130 kD |
862,00 €
AZ 3146
Artikelnummer: Cay19991-10
AZ 3146 is an inhibitor of the monopolar spindle 1 (Mps1) checkpoint kinase (IC50 = 35 nM). It displays selectivity over 46 other kinases including Cdk1 and Aurora kinase B. It has been shown to inhibit the recruitment of Mad1, Mad2, and centromere protein E (CENP-E) to kinetochores. AZ 3146 can be used with...
| Schlagworte: | Mps1 Inhibitor III,... |
| Anwendung: | TTK / Mps1 inhibitor |
| CAS | 1124329-14-1 |
| MW: | 452.6 D |
ab 142,00 €
MPI-0479605
Artikelnummer: SYN-1187-M001
Soluble in DMSO. MPI-0479605 inhibits TTK kinase activity in vitro with an IC(50) of 4nM.
| Schlagworte: | MPI0479605 |
| Anwendung: | TTK inhibitor |
| CAS | 1246529-32-7 |
| MW: | 444,0 D |
ab 250,00 €
MPI-0479605
Artikelnummer: Cay22136-1
MPI-0479605 is a potent and ATP-competitive inhibitor of the mitotic kinase MPS1 (IC50 = 1.8 nM). It is selective for MPS1 over a panel of 79 kinases at a concentration of 500 nM. MPI-0479605 induces time-dependent degradation of cyclin B and securin and decreases phosphorylation of BUBR1 resulting in failed...
| Schlagworte: | N6-cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine |
| Anwendung: | TTK inhibitor |
| CAS | 1246529-32-7 |
| MW: | 407.5 D |
ab 77,00 €
CC-671
Artikelnummer: Cay26184-10
CC-671 is a dual inhibitor of the spindle assembly checkpoint kinase Mps1/TTK and Cdc2-like kinase (Clk2, IC50s = 5 and 3 nM, respectively). It is selective for Mps1/TTK and Clk2 over a panel of 255 kinases at 3 µM, but does inhibit DYRK3, DYRK1A, PHKG, DYRK1B, and Clk1 (IC50s = 99, 104, 136, 157, and 300 nM,...
| Schlagworte: | 4-[[4-(cyclopentyloxy)-5-(2-methyl-6-benzoxazolyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]-3-methoxy-N-methyl-benzamide |
| Anwendung: | TTK / CLK2 inhibitor |
| CAS | 1618658-88-0 |
| MW: | 512.6 D |
ab 43,00 €
Anti-TTK / MPS1
Artikelnummer: ARG58947.100
Protein function: Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint. [The UniProt Consortium]
| Schlagworte: | Anti-PYT, Anti-TTK, Anti-MPS1, EC=2.7.12.1, Anti-Dual specificity protein kinase TTK, Anti-Phosphotyrosine picked... |
| Anwendung: | WB |
| Wirt: | Rabbit |
| Spezies-Reaktivität: | human, mouse |
624,00 €