Anti-phospho-Nephrin (Tyr1193)

In 1X PBS, pH 7.4, with 0.09% sodium azide. Nephrin a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. It primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Protein function: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. [The UniProt Consortium]