Anti-phospho-Keratin 8 (Ser74)

Keratin 8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Nakamichi I, et al. (2002) Mol Biol Cell, 13(10): 3441-3451. Prochasson P, et al. (2002) Nucleic Acids Res, 30(15): 3312-3322. Pankov R, et al. (1994) Proc Natl Acad Sci U S A, 91(3): 873-877. Thorey IS, et al. (1993) Mol Cell Biol, 13(11): 6742-6751 Protein function: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. [The UniProt Consortium]