Anti-phospho-Heat Shock Protein 27 (Ser82) (HSP27)

Anti-phospho-Heat Shock Protein 27 (Ser82) (HSP27)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
H1830-50M.20 20 µl - -

1 - 19 Werktage

343,00 €
H1830-50M.100 100 µl - -

1 - 19 Werktage

613,00 €
 
Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at... mehr
Produktinformationen "Anti-phospho-Heat Shock Protein 27 (Ser82) (HSP27)"
Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small heat shock proteins, HSP27 is regulated at both the transcriptional and posttranslational levels (1). In response to stress, the expression level of HSP27 increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is phosphorylated at Ser15, Ser78 and Ser82 by MAPKAP kinase 2 as a result of the activation of the p38 MAP kinase pathway (2,3). Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers (4). It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polymerization and reorganization (5,6). Applications: Suitable for use in Immunofluorescence, Flow Cytometry, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Flow Cytometry: 1:50, Western Blot: 1:1000, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight. , Immunohistochemistry (Paraffin): 1:100, Immunohistochemistry (Frozen): 1:100, Immunofluorescence (IF-IC): 1:400 , Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Hersteller: United States Biological
Hersteller-Nr: H1830-50M

Eigenschaften

Anwendung: FC, IF, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Monkey, Mouse, Rat
Immunogen: Synthetic phosphopeptide (KLH-coupled) corresponding to residues surrounding Ser82 of human HSP27.
Format: Affinity Purified

Datenbank Information

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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