Anti-H4K20me3 / Trimethyl Histone H4 Lysine 20, clone RM208 (recombinant antibody)

1 mg/ml in PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide. This recombinant H4K20me3 antibody reacts to Histone H4 trimethylated at Lysine 20 (K20me3). It may slightly cross react to dimethylated Lysine 20 (K20me2) at a higher concentration. No cross reactivity with non-modified or monomethylated Lysine 20 (K20me1), or other methylations in histone H4. Protein function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [The UniProt Consortium]