Anti-Citrullinated a-Enolase (Clone 4A7)

Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay34123-300 300 µg -

6 - 10 Werktage*

374,00 €
 
a-Enolase, also known as enolase-1, is a glycolytic enzyme that catalyzes the conversion of... mehr
Produktinformationen "Anti-Citrullinated a-Enolase (Clone 4A7)"
a-Enolase, also known as enolase-1, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. It is ubiquitously expressed in human tissues, including liver, spleen, kidney, and brain. In cells, a-enolase is primarily localized to the cytoplasm, however, an alternatively translated form localizes to the nucleus and lacks glycolytic enzyme activity. a-Enolase functions as a cell surface receptor for plasminogen on pathogens and activated immune cells, as an oxidative stress protein in endothelial cells, and as a chromatin binding partner to facilitate transcription. It is an autoantigen in asthma, Hashimoto's encephalopathy, and rheumatoid arthritis, and has been found in the serum of pediatric patients with juvenile idiopathic arthritis. a-Enolase is also subject to citrullination by peptidyl arginine deiminases (PADs) and citrullinated a-enolase has been found in the synovial fluid of rheumatoid arthritis patients. Cayman's Citrullinated a-Enolase Monoclonal Antibody (Clone 4A7) can be used for ELISA and Western blot applications. The antibody recognizes citrullinated a-enolase at approximately 47 kDa from human samples. Synonyms: 2-phospho-D-Glycerate Hydrolyase, ENO1, Enolase-1, Non-neural Enolase, Phosphopyruvate Hydratase, Plasminogen-binding Protein. Immunogen: A synthetic citrullinated peptide corresponding to the N-terminal region of human alpha-enolase. Clone Designation: 4A7. MW: ~47 kDa. Formulation: This vial contains 300 µg of protein G-affinity purified monoclonal antibody.. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA, WB. Cross Reactivity: (+) Citrullinated alpha-enolase, (+) Citrullinated vimentin, (-) Non-citrullinated alpha-enolase, (-) Citrullinated HSP90, (-) Citrullinated fibrinogen, (-) Citrullinated beta-catenin, (-) Citrullinated glucose-6-phosphate isomerase. UniProt Accession #: P06733.
Schlagworte: Anti-NNE, Anti-NNE, Anti-ENO1, Anti-MBP-1, Anti-MPB-1, Anti-MBP-1, Anti-MPB-1, Anti-ENO1L1, Anti-Enolase 1, Anti-Enolase 1, Anti-Alpha-enolase, Anti-Alpha-enolase, Anti-Non-neural enolase, Anti-Non-neural enolase, Anti-Phosphopyruvate hydratase, Anti-Phos
Hersteller: Cayman Chemical
Hersteller-Nr: 34123

Eigenschaften

Anwendung: ELISA, WB
Antikörper-Typ: Monoclonal
Konjugat: No
Wirt: Mouse
Immunogen: A synthetic citrullinated peptide corresponding to the N-terminal region of human ?-enolase
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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