Anti-TRAP-1 / HSP75

Anti-TRAP-1 / HSP75
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
NSJ-R32204 100 µg - -

3 - 10 Werktage

503,00 €
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Heat shock protein 75 kDa, mitochondrial... mehr
Produktinformationen "Anti-TRAP-1 / HSP75"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene. It is mapped to 16p13.3. This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. And this protein may function in regulating cellular stress responses. In addition, it was found that TRAP1 interacted with the N-terminal half of TNFR1. Also, TRAP1 interacted with the C-terminal ends of the proteins encoded by both multiple exostoses-causing genes, EXT1 and EXT2, but not with EXTL1 or EXTL3. Protein function: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. [The UniProt Consortium]
Schlagworte: Anti-HSP75, Anti-TRAP1, Anti-HSP 75, Anti-TRAP-1, Anti-TNFR-associated protein 1, Anti-Heat shock protein 75 kDa, mitochondrial, Anti-Tumor necrosis factor type 1 receptor-associated protein, TRAP-1 Antibody / HSP75
Hersteller-Nr: R32204

Eigenschaften

Anwendung: WB, IHC (paraffin)
Antikörper-Typ: Polyclonal
Wirt: Rabbit
Reaktivität: Human, Rat
Immunogen: Amino acids 571-704 of human TRAP1 were used as the immunogen for the TRAP1 antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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