Anti-TPX2

Anti-TPX2
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-92021.60 60 µl -

7 - 16 Werktage*

198,00 €
E-AB-92021.120 120 µl -

7 - 16 Werktage*

317,00 €
E-AB-92021.200 200 µl -

7 - 16 Werktage*

525,00 €
 
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal... mehr
Produktinformationen "Anti-TPX2"
Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation. Protein function: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940). [The UniProt Consortium]
Schlagworte: TPX2, p100, DIL-2, C20orf1, Protein fls353, Targeting protein for Xklp2, Hepatocellular carcinoma-associated antigen 90, Hepatocellular carcinoma-associated antigen 519, Restricted expression proliferation-associated protein 100, TPX2 Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-92021

Eigenschaften

Anwendung: WB, IHC, IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, rat
Immunogen: Recombinant fusion protein of human TPX2

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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