Anti-TNIP3

induction:By Listeria infection. Expression is slightly down-regulated by dexamethasone and slightly up-regulated by IL-10.,tissue specificity:Highly expressed in lung, lymph node, thymus and fetal liver. Expressed at lower levels in brain, spleen, leukocytes and tonsils., Protein function: Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: