Anti-TLR9 (Clone: ABM1C51)

TLR9, a member of toll-like receptor family are central to the innate immunity by identifying pathogen associated molecular patterns (PAMPs). TLR9 identify unmethylated CpG dinucleotides present in bacterial DNA leading to NF-kB activation. Protein function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:11564765, PubMed:17932028). Controls lymphocyte response to Helicobacter infection. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (PubMed:23857366). [The UniProt Consortium]