Anti-TCCR (T Cell Cytokine Receptor, IL-27 R alpha, IL27RA, WSX-1) (APC)

IL-27 Ralpha, also known as TCCR (T cell cytokine receptor) and WSX-1, is a 96kD member of the type I group 2 cytokine receptor family. The extracellular region of human TCCR shares 63% amino acid identity with the extracellular domain of mouse IL-27 Ralpha. TCCR is expressed in mast cells, endothelial cells, NK cells, macrophages, monocytes, B cells, dendritic cells, and nai?ve T cells. As with many other class I cytokine receptor chains, IL-27 Ralpha heterodimerizes with gp130, the common receptor subunit of IL-6 family cytokines, to form a functional IL-27 receptor. IL-27 only binds to IL-27 Ralpha/WSX-1/TCCR and not the gp130 subunit. Studies using WSX-1 mice reveal that WSX-1 has the ability to suppress T cell hyperactivity during infection, and to mediate an inhibition of both type 1 and type 2 T cell immunity. In particular, WSX-1 is believed to induce IL-12 R on nai?ve T cells, predisposing them to a Th1 phenotype. This is offset by its ability to limit IL-12 (and TNF) production by macrophages, and its suppression of IFN-gamma production. Applications: Suitable for use in Flow Cytometry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Hybridoma: Mouse myeloma cells with B cells from Balb/c mice. Storage and Stability: May be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for at 12 months at 4°C. Freezing allophycocyanin conjugates will result in a substantial loss of activity. Allophycocyaninconjugates are sensitive to light.