Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
E-AB-62232.60 60 µl - -

7 - 16 Werktage*

117,00 €
E-AB-62232.120 120 µl - -

7 - 16 Werktage*

208,00 €
E-AB-62232.200 200 µl - -

7 - 16 Werktage*

363,00 €
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase... mehr
Produktinformationen "Anti-TADA2A"
Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually required for this activation, possibly to acetylate and destabilize nucleosomes, thereby relieving chromatin constraints at the promoter. The protein encoded by this gene is a transcriptional activator adaptor and has been found to be part of the PCAF histone acetylase complex. Several alternatively spliced transcript variants encoding different isoforms of this gene have been described, but the full-length nature of some of these variants has not been determined. Protein function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376). [The UniProt Consortium]
Schlagworte: Anti-KL04P, Anti-TADA2L, Anti-TADA2A, Anti-ADA2-like protein, Anti-Transcriptional adapter 2-like, Anti-Transcriptional adapter 2-alpha, TADA2A Polyclonal Antibody
Hersteller: Elabscience
Hersteller-Nr: E-AB-62232


Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse, Rat
Immunogen: Recombinant protein of human TADA2A

Handhabung & Sicherheit

Lagerung: -20°C
Versand: -20°C (International: -20°C)
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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