Anti-T131L

Protein function: [Isoform 1]: Membrane-associated form that antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Cell membrane , Single-pass type I membrane protein . Cytoplasm . During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. ., [Isoform 1]: Endoplasmic reticulum . Transmembrane localization is essential for Wnt signaling inhibition. ., [Isoform 5]: Cytoplasm . Scattered throughout the cytoplasm in small-sized punctate structures. .