Anti-SUMO Monoclonal Antibody (Clone 3B5)

The small ubiquitin like modifier (SUMO) protein is similar in structure and function to ubiquitin. However, SUMO does not typically target proteins for degradation as does ubiquitin. SUMO is involved with the modification of a very diverse array of targets. Proteins involved with transcriptional regulation, DNA damage repair, genomic stability, nuclear transport, and histone modification are all subject to modification by SUMO. SUMO typically functions by covalently binding to a target protein, followed by regulation of protein:protein and protein:DNA interactions. The SUMO family of proteins is highly conserved from yeast to human. Invertebrates contain a single SUMO gene (Smt3 in yeast and smo-1 in C. elegans), with three members of SUMO being identified in vertebrates to date (SUMO-1, SUMO-2 and SUMO-3).Synonyms: Small Ubiquitin-like Modifier, Smt3. Immunogen: recombinant yeast Smt3 amino acids 1-97. Clone Designation: 3B5. Formulation: (Request formulation change), 500 µg of protein G-purified antibody. Storage Buffer: TBS, pH 7.4, when reconsituted in 500 µl double distilled water. Host: Mouse. Isotype: IgG1. Applications: ELISA and WB. License: Sold under license from LifeSensors, Inc.. UniProt Accession #: Q12306.