Anti-SHANK3

Anti-SHANK3
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
A304-178A-T 20 µl (2 blots) -

3 - 9 Werktage*

131,00 €
A304-178A-M 100 µl (10 blots) -

3 - 9 Werktage*

313,00 €
A304-178A 100 µl (100 µg) -

3 - 9 Werktage*

465,00 €
 
Protein function: Major scaffold postsynaptic density protein which interacts with multiple... mehr
Produktinformationen "Anti-SHANK3"
Protein function: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor- mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. [The UniProt Consortium]
Schlagworte: Anti-Shank3, Anti-SHANK3, Anti-ProSAP2, Anti-KIAA1650, Anti-Proline-rich synapse-associated protein 2, Anti-SH3 and multiple ankyrin repeat domains protein 3
Hersteller: Bethyl Laboratories
Hersteller-Nr: A304-178A

Eigenschaften

Anwendung: WB, IP
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse (Erwartet: Rat)
Immunogen: synthetic peptide. The epitope recognized by A304-178A-T maps to a region between residue 1475 to 1525 of human SH3 and Multiple Ankyrin Repeat Domains 3 using the numbering given in entry Q9BYB0 (GeneID 85358).
Format: Antigen Affinity Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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