Anti-SARS-CoV/SARS-CoV-2 Spike Glycoprotein RBD Chimeric (Clone D001)

Severe acute respiratory syndrome coronavirus (SARS-CoV) spike glycoprotein, also known as the surface glycoprotein, is a viral structural protein encoded by the S gene in SARS-CoV RNA that contains the receptor binding domain (RBD). SARS-CoV is a member of the Betacoronavirus genus of viruses and has an approximately 79% sequence identity with SARS-CoV-2, the causative agent of COVID-19. SARS-CoV spike glycoprotein is a transmembrane glycoprotein that assembles into homotrimers on the virus surface and is composed of an N-terminal S1 subunit, which contains the receptor binding domain (RBD), and a C-terminal S2 subunit, which facilitates fusion between viral and host cell membranes. The 193-amino acid RBD of the SARS-CoV spike protein is a target for neutralizing antibodies. The SARS-CoV RBD, which spans amino acid residues 318 to 510, is 73% identical to that of SARS-CoV-2 and can bind to human angiotensin-converting enzyme 2 (ACE2), which is the host cell surface receptor for both SARS-CoV and SARS-CoV-2. SARS-CoV is the causative agent of SARS, a primarily respiratory illness characterized by fever, cough, shortness of breath, and an approximately 10% fatality rate. Cayman's SARS-CoV/SARS-CoV-2 Spike Glycoprotein RBD Chimeric Monoclonal Antibody (Clone D001) is composed of human IgG1kappa constant domains and variable regions from a mouse immunized with purified recombinant SARS-CoV spike glycoprotein RBD. It can be used for ELISA, flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications, as well as microneutralization assays.Synonyms: SARS-CoV/SARS-CoV-2 Spike RBD, SARS-CoV/SARS-CoV-2 Spike Receptor Binding Domain, SARS-CoV/SARS-CoV-2 Surface Glycoprotein RBD, SARS-CoV/SARS-CoV-2 Surface Glycoprotein Receptor Binding Domain, Severe Acute Respiratory Syndrome Coronavirus/Severe Acute Respiratory Syndrome Coronavirus 2 Spike Glycoprotein Receptor Binding Domain. Immunogen: Recombinant C-terminal His-tagged SARS-CoV spike glycoprotein RBD. Clone Designation: D001. Formulation: (Request formulation change), 50 or 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: 0.2 µm filtered solution in PBS. Host: Chimeric Monoclonal Antibody. Isotype: Human IgG1kappa. Applications: ELISA, FC, ICC, IF, MN. Cross Reactivity: (+) SARS-CoV-2 Omicron (B.1.1.529) S1+S2 trimer, (+) SARS-CoV-2 Delta (B.1.617.2) spike glycoprotein S1+S2 trimer, (+) SARS-CoV-2 Delta (B.1.617.2) spike glycoprotein S1 subunit, (+) SARS-CoV-2 spike glycoprotein S1 subunit NTD (Fc- and AVI-tagged), (+) SARS-CoV-2 spike glycoprotein S1 subunit, (+) SARS-CoV spike glycoprotein S1 subunit, (+) SARS-CoV-2 (BA.4.6) spike glycoprotein S1+S2 trimer, (-) SARS-CoV-2 Omicron (BQ.1.1) spike glycoprotein S1+S2 trimer, (-) SARS-CoV-2 Omicron (BF.7) spike glycoprotein S1+S2 trimer, (-) SARS-CoV-2 (BA.2.75) spike glycoprotein S1+S2 trimer, (-) SARS-CoV-2 Omicron (BA.2.75.2) spike glycoprotein S1+S2 trimer, (-) SARS-CoV-2 Omicron (BA.1.1) spike glycoprotein S1+S2 trimer, (-) SARS-CoV-2 Omicron (BA.2) spike glycoprotein S1+S2 trimer, (-) SARS-CoV-2 Omicron (BA.2) spike glycoprotein S1 subunit, (-) SARS-CoV-2 Omicron (BA.2) spike glycoprotein S1 subunit NTD, (-) SARS-CoV-2 XD (BA.1 x AY.4) spike glycoprotein S1+S2 trimer, (-) SARS-CoV-2 Delta (B.1.617.2) spike glycoprotein S1 subunit NTD, (-) MERS-CoV spike glycoprotein S1 subunit, (-) HCoV-HKU1 (isolate N1) spike glycoprotein S1 subunit, (-) HCoV-HKU1 (isolate N5) spike glycoprotein S1 subunit, (-) HCoV-NL63 spike glycoprotein S1 subunit, (-) HCoV-229E spike glycoprotein S1 subunit, (-) HCoV-OC43 spike glycoprotein S1+S2 ECD.