Anti-RN183

Protein function: Acts as a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Endoplasmic reticulum membrane , Single-pass type IV membrane protein . Endoplasmic reticulum . Golgi apparatus, cis-Golgi network membrane . Lysosome membrane .