Anti-RbAp 46/48

RbAp48 (UniProtKB/Swiss Prot entry Q09028) is a component of several complexes which regulate chromatin metabolism. These include (1) the chromatin assembly factor 1 (CAF 1) complex, which is required for chromatin assembly following DNA replication and DNA repair, (2) the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression, (3) the nucleosome remodelling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling, (4) the PRC2/EED EZH2 complex, which promotes repression of homeotic genes during development, and (5) the NURF (nucleosome remodeling factor) complex. Therefore it may target chromatin assembly factors as well as chromatin remodeling factors and histone deacetylases to their histone substrates in a nucleosomal DNA dependent manner.