Anti-PTTG1

Anti-PTTG1
NEU
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ATA-HPA008890.25 25 µl -

Fragen Sie uns nach der Lieferzeit

156,00 €
ATA-HPA008890.100 100 µl -

Fragen Sie uns nach der Lieferzeit

363,00 €
 
Protein function: Regulatory protein, which plays a central role in chromosome stability, in the... mehr
Produktinformationen "Anti-PTTG1"
Protein function: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 71% and to rat: 70%
Schlagworte: Anti-EAP1, Anti-hPTTG, Anti-PTTG1, Anti-Securin, Anti-Esp1-associated protein, Anti-Tumor-transforming protein 1, Anti-Pituitary tumor-transforming gene 1 protein
Hersteller: Atlas Antibodies
Hersteller-Nr: HPA008890

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human
Immunogen: Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: PPALPKATRK ALGTVNRATE KSVKTKGPLK QKQPSFSAKK MTEKTVKAKS SVPASDDAYP EIEKFFPFNP LDFESFDLPE EHQIAHLPLS GVPLMILDEE RELEKLFQLG PPSPVKMPSP PWESNLLQSP SS (ATA-APrEST71039)

Datenbank Information

KEGG ID : K06635 | Passende Produkte
UniProt ID : O95997 | Passende Produkte
Gene ID : GeneID 9232 | Passende Produkte
Protein Atlas Nr. : ENSG00000164611

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: +20°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier folgen Informationen zur Produktreferenz. mehr
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Anti-PTTG1"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen