Anti-Prostaglandin I Synthase (mouse)

PGIS catalyzes the isomerization of PGH2 to PGI2. PGI2 (prostacyclin) is a potent vasodilator and inhibitor of platelet aggregation. PGIS is a membrane-bound hemoprotein localized primarily in endothelial cells. The cloned bovine and human enzymes contain 500 amino acids and a calculated molecular mass of 56,629 and 57,103, respectively. Northern blot analysis reveals that the mRNA for PGIS is expressed in a wide variety of human tissues and is particularly abundant in ovary, heart, skeletal muscle, lung, and prostate. Synonyms: PGI Synthase, PGIS, Prostacyclin Synthase. Immunogen: Synthetic peptide from the C-terminal region of mouse PGIS. Formulation: 500 µl of Peptide affinity-purified antibody. Storage Buffer: TBS, pH 7.4, with 50% glycerol, 0.1 BSA, and 0.02% sodium azide. Host: Rabbit. Applications: IHC and WB. UniProt Accession #: O35074. Origin: Animal/Rabbit.