Anti-PRC1

Anti-PRC1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. Protein function: Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. [The UniProt Consortium]