Anti-phospho-NEDD4L (Ser448)

Anti-phospho-NEDD4L (Ser448)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-CABP0843.50 50 µl - -

9 - 20 Werktage*

352,00 €
G-CABP0843.100 100 µl -

9 - 20 Werktage*

448,00 €
 
WB 1:500 - 1:2000. Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an... mehr
Produktinformationen "Anti-phospho-NEDD4L (Ser448)"
WB 1:500 - 1:2000. Protein function: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN5A/Nav1.5, SCN9A/Nav1.7, SCN10A/Nav1.8, KCNA3/Kv1.3, KCNH2, EAAT1, KCNQ2/Kv7.2, KCNQ3/Kv7.3 or CLC5 (PubMed:26363003, PubMed:27445338). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961). Ubiquitinates and regulates protein levels of NTRK1 once this one is activated by NGF (PubMed:27445338). [The UniProt Consortium]
Schlagworte: Anti-phospho-NEDD4L, Anti-phospho-Nedd4-2, Anti-phospho-NEDD4.2, Anti-phospho-KIAA0439, EC=2.3.2.26, Anti-phospho-E3 ubiquitin-protein ligase NEDD4-like, Anti-phospho-HECT-type E3 ubiquitin transferase NED4L, Phospho-NEDD4L-S448 pAb (CABP0843)
Hersteller: Assay Genie
Hersteller-Nr: CABP0843

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: A synthetic phosphorylated peptide around S448 of human NEDD4L (NP_001138439.1).

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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