Anti-Perforin (PE-Cyanine 7), clone dG9

Protein function: Pore-forming protein that plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells (PubMed:9058810, PubMed:9164947, PubMed:20889983, PubMed:21037563). Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease (PubMed:9058810). Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores (PubMed:20889983, PubMed:21037563). Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes (PubMed:20038786, PubMed:20225066, PubMed:32299851). {ECO:0000269, PubMed:20038786, ECO:0000269, PubMed:20225066, ECO:0000269, PubMed:20889983, ECO:0000269, PubMed:21037563, ECO:0000269, PubMed:32299851, ECO:0000269, PubMed:9058810, ECO:0000269, PubMed:9164947}. [The UniProt Consortium]