Anti-PARK7 (CAP1, DJ1, DJ-1, DJ1 Protein, FLJ27376, Oncogene DJ1, Parkinson Disease (Autosomal Reces

Anti-PARK7 (CAP1, DJ1, DJ-1, DJ1 Protein, FLJ27376, Oncogene DJ1, Parkinson Disease (Autosomal Reces
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
P3110-99N.100 100 µl - -

3 - 19 Werktage*

498,00 €
 
PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including... mehr
Produktinformationen "Anti-PARK7 (CAP1, DJ1, DJ-1, DJ1 Protein, FLJ27376, Oncogene DJ1, Parkinson Disease (Autosomal Reces"
PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies (Rizzu et al. 2004). Four chromosomal loci (PARK2, PARK6, PARK7, and PARK9) associated with autosomal recessive, early onset parkinsonism are known. Positional cloning within the refined PARK7 critical region recently identified mutations in the DJ-1 gene in PARK7-linked families. Defects in PARK7/DJ1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways. Applications: Suitable for use in Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Schlagworte: EC=3.4.-.-, Anti-Parkinson disease protein 7
Hersteller: United States Biological
Hersteller-Nr: P3110-99N

Eigenschaften

Anwendung: ICC, IP, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse
Immunogen: A synthetic peptide corresponding to residues between 150-189 of human DJ-1 (the C-terminus).
Reinheit: Serum
Format: Serum

Handhabung & Sicherheit

Lagerung: -20°C (-20°C Glycerol)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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