Anti-p19-INK4d / CDKN2D

In 1X PBS, pH 7.4, with 0.09% sodium azide. p19 / Cyclin-dependent kinase 4 inhibitor D is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Protein function: Interacts strongly with CDK4 and CDK6 and inhibits them. [The UniProt Consortium]