Anti-NUMA1

Protein function: Microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignement and the segregation of chromosomes during mitotic cell division (PubMed:7769006, PubMed:17172455, PubMed:19255246, PubMed:24996901, PubMed:26195665, PubMed:27462074). Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles (PubMed:12445386, PubMed:11956313). Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner (PubMed:23870127, PubMed:24109598, PubMed:24996901, PubMed:26765568). In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct oritentation of the mitotic spindle (PubMed:23027904, PubMed:22327364, PubMed:23921553). During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation (PubMed:22327364, PubMed:23921553, PubMed:24996901, PubMed:24371089). Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro (PubMed:24996901, PubMed:24371089). Also required for proper orientation of the mitotic spindle during asymmetric cell divisions (PubMed:21816348). Plays a role in mitotic MT aster assembly (PubMed:11163243, PubMed:11229403, PubMed:12445386). Involved in anastral spindle assembly (PubMed:25657325). Positively regulates TNKS protein localization to spindle poles in mitosis (PubMed:16076287). Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume (PubMed:10075938). Required for epidermal differentiation and hair follicle morphogenesis. {ECO:0000250, UniProtKB:E9Q7G0, ECO:0000269, PubMed:11163243, ECO:0000269, PubMed:11229403, ECO:0000269, PubMed:11956313, ECO:0000269, PubMed:12445386, ECO:0000269, PubMed:16076287, ECO:0000269, PubMed:17172455, ECO:0000269, PubMed:19255246, ECO:0000269, PubMed:22327364, ECO:0000269, PubMed:23027904, ECO:0000269, PubMed:23870127, ECO:0000269, PubMed:23921553, ECO:0000269, PubMed:24109598, ECO:0000269, PubMed:24371089, ECO:0000269, PubMed:24996901, ECO:0000269, PubMed:25657325, ECO:0000269, PubMed:26195665, ECO:0000269, PubMed:26765568, ECO:0000269, PubMed:27462074, ECO:0000269, PubMed:7769006, ECO:0000305, PubMed:10075938, ECO:0000305, PubMed:21816348}. [The UniProt Consortium]