Anti-NUDT5

Anti-NUDT5
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ELK-ES14432.50 50 µl - -

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169,00 €
ELK-ES14432.100 100 µl - -

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283,00 €
 
This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily.... mehr
Produktinformationen "Anti-NUDT5"
This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013], Protein function: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Nucleus .
Schlagworte: Anti-YSA1H, Anti-NUDT5, Anti-hNUDT5, Anti-Nudix motif 5, Anti-8-oxo-dGDP phosphatase, Anti-ADP-sugar pyrophosphatase, Anti-Nuclear ATP-synthesis protein NUDIX5, Anti-Nucleoside diphosphate-linked moiety X motif 5, NUDT5 rabbit pAb
Hersteller: ELK Biotechnology
Hersteller-Nr: ES14432

Eigenschaften

Anwendung: WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: Synthesized peptide derived from human NUDT5 AA range: 95-145
Format: Purified

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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