Anti-NKX3.1, clone RM430

Antibody in PBS with 50% glycerol, 1% BSA and 0.09% sodium azide. This antibody reacts to human NKX3.1 / Homeobox protein Nkx-3.1. Protein function: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. [The UniProt Consortium]