Anti-Niemann-Pick Disease, Type C1 (NPC1, Niemann-Pick C1, Niemann-Pick C1 Protein Precursor, NPC)

Anti-Niemann-Pick Disease, Type C1 (NPC1, Niemann-Pick C1, Niemann-Pick C1 Protein Precursor, NPC)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
N2566-31A.100 100 µl - -

3 - 19 Werktage*

526,00 €
 
Niemann-Pick type C1 (NPC1) is a member of a family of genes encoding membrane-bound proteins... mehr
Produktinformationen "Anti-Niemann-Pick Disease, Type C1 (NPC1, Niemann-Pick C1, Niemann-Pick C1 Protein Precursor, NPC)"
Niemann-Pick type C1 (NPC1) is a member of a family of genes encoding membrane-bound proteins containing putative sterol sensing domains. NPC1 protein regulates cholesterol transport from late endosomes-lysosomes to other intracellular compartments. NPC1 overexpression increases the rate of trafficking of low density lipoprotein cholesterol to the endoplasmic reticulum and the rate of delivery of endosomal cholesterol to the plasma membrane., NPC disease is an inherited neurovisceral lipid storage disorder of unesterified cholesterol accumulation in lysosomes. It is characterized by progressive neural and liver degeneration, resulting from inactivating mutations in NPC1, in most cases. Positive Control: Human fibroblast cell lysate , Applications: , Suitable for use in Immunofluorescence, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: Detecting heterogeneously glycosylated NPC1 protein with prominent bands at 170 and 220kD., Optimal dilutions to be determined by the researcher. Storage and Stability: , May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Hersteller: United States Biological
Hersteller-Nr: N2566-31A

Eigenschaften

Anwendung: IF, IHC, IP, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Hamster, Human, Mouse
Immunogen: A synthetic peptide made to the C-terminal region of human NPC1.
Reinheit: Purified by immunoaffinity chromatography.
Format: Affinity Purified

Datenbank Information

Handhabung & Sicherheit

Lagerung: -20°C (-20°C Glycerol)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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