Anti-Neurogenin-3 (Ngn3, Neurogenin Family Helix-loop-helix Transcription Factor)

Neurogenins are a family of bHLH transcription factors involved in specifying neuronal differentiation. They are related to Drosophila atonal. The neurogenins (ngns) make up one of these atonal-related gene families. In neural crest cells, the atonal-related neurogenin family is particularly important for the sensory lineage (Neurogenins Are Essential for the Formation of dorsal root ganglia), while the achaete-scute homologue ash1 (Mash1) is important for aspects of autonomic neurogenesis (Mash1 Is Essential for Noradrenergic Differentiation). Neurogenin-3 promotes pancreatic development. Applications: Suitable for use in Immunohistochemistry, and ImmunofluorescenceI/mmunocytochemistry. Not recommended for use in Western Blot. Other applications not tested. Recommended Dilutions: Immunohistochemistry: 1:200-1:1000, iImmunofluorescence (IC): 1:200-1:500, Optimal dilutions to be determined by the researcher. Positive Control: Rat brain tissue, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.