Anti-MSH3, clone CL14064

DNA mismatch repair protein Msh3 - Protein function: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. [The UniProt Consortium] Enhanced validation: N/A. Concentration: 1 mg/ml. Immunogen homology (mouse/rat): ENSMUSG00000014850: 100%, ENSRNOG00000013673: 100%. Buffer formulation: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.