Anti-MSH2 Rabbit Monoclonal Antibody (Clone RM375)

MutS homolog 2 (MSH2) is a DNA repair protein. It heterodimerizes with MSH6 or MSH3 to form the MutSalpha and MutSbeta DNA mismatch recognition complexes, respectively, which are divided into five domains: a mismatch-binding domain, connector domain, alpha-helical lever domain, clamp domain, and an ABC-ATPase domain. It is ubiquitously expressed and localized to the nucleus. MSH2, when complexed with MSH6 or MSH3, recognizes DNA polymerase errors in replicated DNA to activate MutL and initiate DNA repair. Missense mutations in MSH2 are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Polymorphisms in MSH2 are associated with an increased risk of developing prostate cancer. Cayman's MSH2 Rabbit Monoclonal Antibody (Clone RM375) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: DNA Mismatch Repair Protein MSH2, HNPCC1, MutS Homolog 2. Immunogen: Recombinant peptide within 500 amino acids of the N-terminus of human MSH2. Clone Designation: RM375. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) MSH2.