Anti-MLH1 (Clone: ABM4D74)

Anti-MLH1 (Clone: ABM4D74)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
ABE-10-7573-25 25 µg -

3 - 11 Werktage*

149,00 €
 
MutL homolog 1 (MLH1) is a member of mismatch repair genes (MMR) that plays a crucial role in... mehr
Produktinformationen "Anti-MLH1 (Clone: ABM4D74)"
MutL homolog 1 (MLH1) is a member of mismatch repair genes (MMR) that plays a crucial role in correcting replication errors, cell cycle arrest, apoptosis and oxidative stress. MLH1 is a human homolog of the E.coli DNA mismatch repair gene. It mediates protein-protein interactions during mismatch recognition, strand discrimination, and strand removal. Diseases associated with MLH1 include colorectal cancer, hereditary nonpolyposis, type 2 and lynch syndrome. Protein function: Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS- heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Heterodimerizes with MLH3 to form MutL gamma which plays a role in meiosis. [The UniProt Consortium]
Schlagworte: Anti-MLH1, Anti-COCA2, Anti-MutL protein homolog 1, Anti-DNA mismatch repair protein Mlh1, Monoclonal Antibody to MLH1 (Clone: ABM4D74)
Hersteller: Abeomics
Hersteller-Nr: 10-7573-25

Eigenschaften

Anwendung: IHC
Antikörper-Typ: Monoclonal
Klon: ABM4D74
Konjugat: No
Wirt: Mouse
Spezies-Reaktivität: human
Immunogen: A partial length recombinant MLH1 protein (amino acids 289-492) was used as the immunogen for this antibody.
Format: Purified

Handhabung & Sicherheit

Lagerung: +4°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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