Anti-MDC (macrophage-derived chemokine)

MDC (macrophage-derived chemokine) is a 69-amino acid CC chemokine with a NH2-terminal sequence of 24 residues as a signal sequence. It was originally cloned from human monocyte-derived macrophages. Recombinant MDC attracts monocyte-derived dendritic cells, activated lymphocytes and natural killer cells. MDC has anti-HIV-1 activity. Expression of MDC mRNA in macrophages is enhanced by LPS, IL-1b and TNFa. MDC is a functional ligand for CCR4. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:2000, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at 4°C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.