Anti-MBTPS2 (PACO04534)

Anti-MBTPS2 (PACO04534)
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
G-PACO04534.50 50 µg -

9 - 20 Werktage*

320,00 €
 
MBTPS2 Antibody (PACO04534). Protein function: Zinc metalloprotease that mediates intramembrane... mehr
Produktinformationen "Anti-MBTPS2 (PACO04534)"
MBTPS2 Antibody (PACO04534). Protein function: Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2 (PubMed:11163209, PubMed:10805775). Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N- terminal segment with a portion of the transmembrane segment attached (PubMed:10805775, PubMed:27380894, PubMed:9659902). Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription (PubMed:10805775, PubMed:27380894, PubMed:9659902). Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B) (PubMed:11163209). Involved in intramembrane proteolysis during bone formation (PubMed:27380894). [The UniProt Consortium]
Schlagworte: Anti-Endopeptidase S2P, Anti-SREBPs intramembrane protease, Anti-Membrane-bound transcription factor site-2 protease, Anti-Sterol regulatory element-binding proteins intramembrane protease
Hersteller: Assay Genie
Hersteller-Nr: PACO04534

Eigenschaften

Anwendung: ELISA, IF
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Spezies-Reaktivität: human, mouse, rat
Immunogen: synthesized peptide derived from the Internal region of human S2P.

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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