Anti-MAGUK, clone S28-86

Anti-PAN-MAGUK Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with MAGUK from Mouse, Human, Zebrafish, Xenopus, and rat based on 100% homology with the immunizing sequence. Cross-reactivity with MAGUK from other sources has not been determined. Scaffolds research. Protein function: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. [The UniProt Consortium]