Anti-Lysosome Associated Membrane Protein-1 (LAMP1, CD107a, Igp120, IgpA), clone 4E151

Lysosome-associated membrane proteins (LAMP1 and LAMP2) are type I integral membrane protein that are transported from the trans-Golgi network to endosomes and then lysosomes. Following activation of platelets, T-cells, neutrophils, or endothelium, LAMP1 and LAMP2 are expressed on the cell surface. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and loss of LAMP2 expression is associated with impaired autophagy observed in Danons disease., , Applications:, Suitable for use in Immunocytochemistry, Immunofluorescence, Immunoprecipitation and Western Blot. Other applications have not been tested. Recommended Dilutions: Immunocytochemistry: 1:100, Optimal dilutions to be determined by researcher., , Positive Control:, CHO K1 cells, ., Storage and Stability:, May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.