Anti-LRRK1

This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017] Protein function: Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts. [The UniProt Consortium]