Anti-LPAM-1 / Integrin alpha 4 / CD49d, clone PS/2

Protein function: Integrins alpha-4/beta-1 (VLA-4 or LPAM-2) and alpha- 4/beta-7 (LPAM-1) are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA- 4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. Mice homozygous for a null mutation of the alpha-4 subunit gene die by day E11-E14 from detachment and rupture of the epicardium and coronary arteries. [The UniProt Consortium]