Anti-Lif (Clone: ABM2C57)

LIF (Leukemia inhibitory factor) is also known as differentiation-stimulating factor consists of 203 amino acids and it belongs to the LIF/OSM family. LIF acts as lymphoid factor, which promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. LIF is responsible for terminal differentiation in leukemic cells, cholinergic neuron differentiation and control of stem cell pluripotency, bone and fat metabolism, mitogenesis of factor dependent cell lines. It is found to be expressed in spleen. Protein function: LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes. [The UniProt Consortium]