Anti-LEF1, NT (LEF1, Lymphoid enhancer-binding factor 1, T cell-specific transcription factor 1-alph

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. Applications: Suitable for use in Western Blot, ELISA and Immunofluorescence. Other applications not tested. Recommended Dilutions: Western Blot: 1:1000, Immunofluorescence: 1:10-1:50, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receeipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.