Anti-Langerin / CD207, clone LGRN/3136R

1 mg/ml in 1X PBS, BSA free, sodium azide free. Langerin/CD207 is a calcium-dependent lectin displaying mannose-binding specificity. [UniProt] Protein function: Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs), is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. [The UniProt Consortium]