Anti-Kir2.1, clone S112B-14

Anti-Kir2.1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Kir2.1 from Human, Rat, and Mouse based on 100% homology with the immunizing sequence. No cross-reactivity against Kir2.2 or Kir2.3. Cross-reactivity with Kir2.1 from other sources has not been determined. Channels and Transporters research. Protein function: Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium, as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. [The UniProt Consortium]