Anti-KHSRP

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization. KHSRP (KH-Type Splicing Regulatory Protein) is a Protein Coding gene. Diseases associated with KHSRP include Ataxia, Cerebellar, Cayman Type. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Gene Expression. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is FUBP1. Protein function: Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue- specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. [The UniProt Consortium]