Anti-Jagged1 (JAG1, AGS, AHD, AWS, HJ1, JAGL1, Alagille Syndrome Protein, CD339, Headturner, Htu, MG

Anti-Jagged1 (JAG1, AGS, AHD, AWS, HJ1, JAGL1, Alagille Syndrome Protein, CD339, Headturner, Htu, MG
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
J0400-01F.500 500 µg - -

3 - 19 Werktage*

872,00 €
 
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper... mehr
Produktinformationen "Anti-Jagged1 (JAG1, AGS, AHD, AWS, HJ1, JAGL1, Alagille Syndrome Protein, CD339, Headturner, Htu, MG"
The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Jagged-1 (JAG1) is a cell surface protein which is one of several ligands that activate Notch and related receptors. JAG1 functions in an embryologically important signaling pathway and has also been shown to play a role in hematopoiesis. JAG1 inhibits proliferation of cd34+ macrophage progenitor cells and a JAG1 gene abnormality may be an aggravating factor in extrahepatic biliary atresia. Activation of NOTCH1 signaling by JAG1 induces monocyte-derived dendritic cell maturation in vitro. JAG1 interaction with NOTCH1 on tumor cells dramatically induces proliferation and inhibition of apoptosis in vitro. Either haploinsufficiency for wild-type JAG1 and/or dominant negative effects produced by mutated JAG1 are responsible for the Alagille syndrome. Applications: Suitable for use in ELISA, Immunohistochemistry, Immunofluorescence/Immunocytochemistry and Western Blot. Other applications not tested. Recommended Dilutions: ELISA: 1:20,000-1:100,000, Immunofluorescence (IC): 1:200-1:1000, Immunohistochemistry: 1:100-1:500, Immunohistochemistry (paraffin): 1:10-1:500, Western Blot: 1:500-1:2000, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Hersteller: United States Biological
Hersteller-Nr: J0400-01F

Eigenschaften

Anwendung: ELISA, ICC, IF, IHC, WB
Antikörper-Typ: Polyclonal
Konjugat: No
Wirt: Rabbit
Reaktivität: Human, Mouse
Immunogen: Synthetic peptide: KASRGNDRNRIVLPFS-C conjugated to KLH, corresponding to amino acids 110-125 of Human Jagged1.
Reinheit: Purified by Protein A affinity chromatography.
Format: Affinity Purified

Datenbank Information

Handhabung & Sicherheit

Lagerung: -20°C (-20°C Glycerol)
Versand: +4°C (International: +4°C)
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
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