Anti-Interleukin 6 Receptor, gp80 (CD126, IL-6R) (Biotin)

The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component speci?c to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low af?nity binding sites for IL-6, is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. Applications: Suitable for use in Flow Cytometry and Functional Studies. Other applications not tested. Recommended Dilution: Flow Cytometry: 0.2ug/10e6 cells., Fuctional Studies: 10ng neutralizes 1 unit of I8428-39K1 on XG1 cells. Inhibition of proliferation by 50%., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.