Anti-Integrin beta3/CD61 Rabbit Monoclonal Antibody (Clone RM382)

Integrins are cell adhesion receptors that mediate the attachment of cells to the extracellular matrix (ECM) and facilitate cell-cell interactions. The integrin family contains 18 alpha subunits and eight beta subunits that form 24 different heterodimers grouped into familial subgroups based on subunit composition and/or their ligand binding properties. Integrin beta3, also known as CD61, is an integrin subunit that associates with alphaIIB or alphav integrin subunits, forming alphaIIBbeta3 and alphavbeta3 integrin heterodimers, respectively, which function as receptors for a variety of ECM proteins, including fibrinogen, fibronectin, and collagen and mediate outside-in and inside-out signaling cascades. Integrin beta3 is composed of a ligand-binding extracellular domain, a single transmembrane segment, and a short cytoplasmic tail. It is expressed by platelets, megakaryocytes, and endothelial cells, as well as monocytes and macrophages. Mutations in ITGB3 have been found in patients with Glanzmann thrombasthenia, a hemorrhagic disease characterized by defects in platelet function, and ITGB3 SNPs are associated with increased risk of myocardial infarction. Cayman's Integrin beta3/CD61 Rabbit Monoclonal Antibody (Clone RM382) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: GP3A, GPIIIa, Platelet Glycoprotein IIIa. Immunogen: Peptide corresponding to the internal region of human integrin beta3. Clone Designation: RM382. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: ( +) Integrin beta3.